There have been 46 recent insider transactions recorded for Spyre Therapeutics, Inc. (SYRE), including 28 buys and 16 sells. Total insider buying was valued at $70.86M and total insider selling at $8.01M.
Notable insiders with recent activity include Turtle Cameron, Burrows Scott L, Sloan Sheldon. Insider transactions can provide insights into how company leadership views the stock's valuation and future prospects.
Insider Transactions — SYRE
| Date |
Name |
Role |
Transaction |
Shares |
Avg. Price |
Value |
Shares Owned |
| 2026-04-01 |
Turtle Cameron |
Chief Executive Officer |
Informative Sell |
2,656 |
$49.92 |
$132.59K |
627,540 |
| 2026-04-01 |
Burrows Scott L |
Chief Financial Officer |
Informative Sell |
1,300 |
$49.98 |
$64.97K |
97,994 |
| 2026-04-01 |
Sloan Sheldon |
Chief Medical Officer |
Informative Sell |
7,958 |
$50.00 |
$397.9K |
- |
| 2026-03-03 |
Burrows Scott L |
Chief Financial Officer |
Informative Sell |
200 |
$41.66 |
$8.33K |
97,994 |
| 2026-03-02 |
Turtle Cameron |
Chief Executive Officer |
Informative Sell |
9,100 |
$42.49 |
$386.66K |
642,540 |
| 2026-02-02 |
Turtle Cameron |
Chief Executive Officer |
Informative Sell |
14,043 |
$32.87 |
$461.59K |
657,540 |
| 2026-01-21 |
Henderson Michael Thomas |
Director |
Other (Buy) |
63,227 |
- |
- |
168,606 |
| 2026-01-09 |
Turtle Cameron |
Chief Executive Officer |
RSU Award |
528,000 |
$30.61 |
$16.16M |
528,000 |
| 2026-01-09 |
King-jones Heidy |
See Remarks |
RSU Award |
140,000 |
$30.61 |
$4.29M |
140,000 |
| 2026-01-09 |
Burrows Scott L |
Chief Financial Officer |
RSU Award |
140,000 |
$30.61 |
$4.29M |
140,000 |
| 2026-01-09 |
Sloan Sheldon |
Chief Medical Officer |
RSU Award |
140,000 |
$30.61 |
$4.29M |
140,000 |
| 2026-01-02 |
Turtle Cameron |
Chief Executive Officer |
Informative Sell |
100 |
$32.39 |
$3.24K |
671,907 |
| 2025-12-01 |
Turtle Cameron |
Chief Executive Officer |
Informative Sell |
4,005 |
$29.83 |
$119.47K |
686,907 |
| 2025-11-03 |
Turtle Cameron |
Chief Executive Officer |
Informative Sell |
16,845 |
$23.66 |
$398.55K |
701,907 |
| 2025-09-02 |
Burrows Scott L |
Chief Financial Officer |
Informative Sell |
18,428 |
$16.26 |
$299.64K |
97,994 |
| 2025-05-29 |
Albers Jeffrey W. |
Director |
RSU Award |
25,000 |
$15.55 |
$388.75K |
25,000 |
| 2025-05-29 |
Stelzer Laurie |
Director |
RSU Award |
25,000 |
$15.55 |
$388.75K |
25,000 |
| 2025-05-29 |
Mckenna Mark C. |
Director |
RSU Award |
25,000 |
$15.55 |
$388.75K |
25,000 |
| 2025-05-29 |
Henderson Michael Thomas |
Director |
RSU Award |
25,000 |
$15.55 |
$388.75K |
25,000 |
| 2025-05-29 |
Fairmount Funds Management Llc |
Director |
RSU Award |
25,000 |
$15.55 |
$388.75K |
25,000 |
| 2025-05-29 |
Milligan Sandra |
Director |
RSU Award |
25,000 |
$15.55 |
$388.75K |
25,000 |
| 2025-01-15 |
Turtle Cameron |
Chief Executive Officer |
RSU Award |
370,000 |
$21.66 |
$8.01M |
370,000 |
| 2025-01-15 |
King-jones Heidy |
See Remarks |
RSU Award |
95,500 |
$21.66 |
$2.07M |
95,500 |
| 2025-01-15 |
Burrows Scott L |
Chief Financial Officer |
RSU Award |
95,500 |
$21.66 |
$2.07M |
95,500 |
| 2025-01-15 |
Sloan Sheldon |
Chief Medical Officer |
RSU Award |
95,500 |
$21.66 |
$2.07M |
95,500 |
| 2025-01-10 |
Henderson Michael Thomas |
Director |
Other (Buy) |
105,379 |
- |
- |
105,379 |
| 2024-11-06 |
Albers Jeffrey W. |
Director |
Informative Sell |
6,700 |
$36.76 |
$246.31K |
27,360 |
| 2024-10-25 |
Albers Jeffrey W. |
Director |
Informative Sell |
300 |
$36.43 |
$10.93K |
34,060 |
| 2024-10-01 |
Sloan Sheldon |
Officer |
Unknown |
- |
- |
- |
- |
| 2024-10-01 |
Sloan Sheldon |
Chief Medical Officer |
RSU Award |
400,000 |
$27.46 |
$10.98M |
400,000 |
| 2024-09-03 |
Burrows Scott L |
Chief Financial Officer |
Informative Sell |
18,531 |
$28.17 |
$522.07K |
116,422 |
| 2024-05-14 |
Albers Jeffrey W. |
Director |
RSU Award |
11,323 |
$39.29 |
$444.88K |
11,323 |
| 2024-05-14 |
Stelzer Laurie |
Director |
RSU Award |
11,323 |
$39.29 |
$444.88K |
11,323 |
| 2024-05-14 |
Henderson Michael Thomas |
Director |
RSU Award |
11,323 |
$39.29 |
$444.88K |
11,323 |
| 2024-05-14 |
Fairmount Funds Management Llc |
Director |
RSU Award |
11,323 |
$39.29 |
$444.88K |
11,323 |
| 2024-05-14 |
Milligan Sandra |
Officer |
Unknown |
- |
- |
- |
- |
| 2024-05-14 |
Milligan Sandra |
Director |
RSU Award |
21,980 |
$39.29 |
$863.59K |
21,980 |
| 2024-04-25 |
Fairmount Funds Management Llc |
Director |
Option Exercise (Sell) |
90,992 |
- |
- |
346,045 |
| 2024-02-15 |
Turtle Cameron |
Chief Executive Officer |
RSU Award |
400 |
$9.82 |
$3.93K |
746,907 |
| 2024-02-01 |
Turtle Cameron |
Chief Executive Officer |
RSU Award |
277,750 |
$25.86 |
$7.18M |
277,750 |
| 2024-02-01 |
King-jones Heidy |
See Remarks |
RSU Award |
63,000 |
$25.86 |
$1.63M |
63,000 |
| 2024-02-01 |
Burrows Scott L |
Chief Financial Officer |
RSU Award |
70,000 |
$25.86 |
$1.81M |
70,000 |
| 2024-02-01 |
Mckenna Mark C. |
Director |
Disposition |
477,000 |
$10.39 |
$4.96M |
- |
| 2024-02-01 |
Mckenna Mark C. |
Director |
RSU Award |
40,000 |
$25.86 |
$1.03M |
40,000 |
| 2023-12-29 |
Fairmount Funds Management Llc |
10 Percent Owner |
Other (Sell) |
3,435,480 |
- |
- |
- |
| 2023-12-07 |
Fairmount Funds Management Llc |
10 Percent Owner |
RSU Award |
16,667 |
- |
- |
16,667 |
■ Informative Buy/Sell — open market transaction (most significant)
■ Uninformative Buy — award, option exercise, conversion
■ Uninformative Sell — tax withholding, award vest sale
■ Neutral — gift, trust, expiry
