Edgewise Therapeutics, Inc. (EWTX) has 19 known insider and institutional holders on record. The largest holder is OrbiMed Genesis GP LLC with 13,497,456 shares. Other notable holders include Novo Holdings A/S and ORBIMED ADVISORS LLC.
Over the last 12 months, insiders have made 40 transactions in EWTX stock — 14 buys (valued at $3.85M) and 13 sells (valued at $5.79M). Insider buying has outpaced selling during this period, which may signal confidence in the company's prospects.
EWTX Insider Ownership
Top Holder
OrbiMed Genesis GP LLC
13,497,456 shares
Buys (12 mo)
14
$3.85M value
Sells (12 mo)
13
$5.79M value
12-Month Transaction Activity
Top Insider Holders
| # |
Name |
Role |
Shares Owned |
Last Filed |
Relative Size |
| 1 |
Orbimed Genesis Gp Llc |
Director |
13,497,456 |
2022-05-20 |
|
| 2 |
Novo Holdings A/s |
10 Percent Owner |
6,071,703 |
2022-09-16 |
|
| 3 |
Orbimed Advisors Llc |
10 Percent Owner |
443,792 |
2025-04-04 |
|
| 4 |
Martin Christopher Nathan |
Director |
45,150 |
2025-11-24 |
|
| 5 |
Nofi Michael |
Chief Financial Officer |
43,750 |
2025-11-13 |
|
| 6 |
Koch Kevin |
President and CEO |
30,615 |
2025-08-14 |
|
| 7 |
Root Jonathan D |
Director |
30,000 |
2025-06-18 |
|
| 8 |
Brege Laura |
Director |
30,000 |
2025-06-18 |
|
| 9 |
Edris Badreddin |
Director |
30,000 |
2025-06-18 |
|
| 10 |
Thompson Peter A. |
10 Percent Owner |
30,000 |
2025-06-18 |
|
| 11 |
Morris Arlene |
Director |
30,000 |
2025-06-18 |
|
| 12 |
Fox Jonathan C |
Director |
24,514 |
2026-04-03 |
|
| 13 |
Russell Alan J |
Chief Scientific Officer |
23,400 |
2025-11-13 |
|
| 14 |
Blaustein Robert |
Chief Development Officer |
17,500 |
2025-08-14 |
|
| 15 |
Derakhshan Behrad |
Chief Business Officer |
17,344 |
2025-08-14 |
|
| 16 |
Carruthers R Michael |
Chief Financial Officer |
17,344 |
2025-08-14 |
|
| 17 |
Moore John R |
General Counsel |
10,214 |
2025-08-14 |
|
| 18 |
Donovan Joanne M. |
CMO |
9,597 |
2026-04-02 |
|
| 19 |
Semigran Marc |
Chief Development Officer |
6,716 |
2024-12-27 |
|
Recent Transactions (last 12 months)
| Date |
Name |
Role |
Type |
Shares |
Price |
Value |
| 2026-04-01 |
Fox Jonathan C |
Director |
RSU Award |
339 |
- |
- |
| 2026-04-01 |
Donovan Joanne M. |
CMO |
Informative Sell |
28,662 |
$32.31 |
$926.1K |
| 2026-03-31 |
Donovan Joanne M. |
CMO |
Informative Sell |
21,338 |
$32.12 |
$685.31K |
| 2026-03-27 |
Donovan Joanne M. |
CMO |
Informative Sell |
6,735 |
$30.98 |
$208.64K |
| 2026-01-21 |
Edris Badreddin |
Director |
Option Exercise (Sell) |
13,690 |
$0.39 |
$5.34K |
| 2026-01-02 |
Fox Jonathan C |
Director |
RSU Award |
473 |
- |
- |
| 2025-11-19 |
Martin Christopher Nathan |
Director |
RSU Award |
45,150 |
$22.34 |
$1.01M |
| 2025-11-19 |
Martin Christopher Nathan |
Officer |
Unknown |
- |
- |
- |
| 2025-11-12 |
Russell Alan J |
Chief Scientific Officer |
Informative Sell |
100,000 |
$21.12 |
$2.11M |
| 2025-11-10 |
Nofi Michael |
Chief Financial Officer |
RSU Award |
43,750 |
- |
- |
| 2025-11-10 |
Nofi Michael |
Officer |
Unknown |
- |
- |
- |
| 2025-11-11 |
Fox Jonathan C |
Director |
Informative Buy |
10,700 |
$18.64 |
$199.4K |
| 2025-10-01 |
Fox Jonathan C |
Director |
RSU Award |
728 |
- |
- |
| 2025-08-26 |
Russell Alan J |
Chief Scientific Officer |
Informative Sell |
100,000 |
$14.60 |
$1.46M |
| 2025-08-12 |
Blaustein Robert |
Chief Development Officer |
RSU Award |
17,500 |
- |
- |
| 2025-08-12 |
Russell Alan J |
Chief Scientific Officer |
Option Exercise (Sell) |
5,781 |
- |
- |
| 2025-08-12 |
Derakhshan Behrad |
Chief Business Officer |
Option Exercise (Sell) |
5,781 |
- |
- |
| 2025-08-12 |
Carruthers R Michael |
Chief Financial Officer |
Option Exercise (Sell) |
5,781 |
- |
- |
| 2025-08-12 |
Donovan Joanne M. |
CMO |
Option Exercise (Sell) |
5,781 |
- |
- |
| 2025-08-12 |
Moore John R |
General Counsel |
Informative Sell |
2,098 |
$13.39 |
$28.1K |
| 2025-08-12 |
Koch Kevin |
President and CEO |
Informative Sell |
7,972 |
$13.39 |
$106.76K |
| 2025-07-01 |
Fox Jonathan C |
Director |
RSU Award |
858 |
- |
- |
| 2025-06-16 |
Edris Badreddin |
Director |
RSU Award |
30,000 |
$14.68 |
$440.4K |
| 2025-06-16 |
Fox Jonathan C |
Director |
RSU Award |
30,000 |
$14.68 |
$440.4K |
| 2025-06-16 |
Brege Laura |
Director |
RSU Award |
30,000 |
$14.68 |
$440.4K |
