Amylyx Pharmaceuticals, Inc. (AMLX) has 17 known insider and institutional holders on record. The largest holder is ALS Invest 1 B.V. with 5,937,577 shares. Other notable holders include Morningside Venture Investments Ltd and DRAGSA 96 LLC.
Over the last 12 months, insiders have made 38 transactions in AMLX stock — 11 buys (valued at $16.9M) and 21 sells (valued at $2.78M). Insider selling has exceeded buying during this period.
AMLX Insider Ownership
Top Holder
ALS Invest 1 B.V.
5,937,577 shares
Buys (12 mo)
11
$16.9M value
Sells (12 mo)
21
$2.78M value
12-Month Transaction Activity
Top Insider Holders
| # |
Name |
Role |
Shares Owned |
Last Filed |
Relative Size |
| 1 |
Als Invest 1 B.v. |
Director |
5,937,577 |
2022-07-08 |
|
| 2 |
Morningside Venture Investments Ltd |
10 Percent Owner |
4,997,302 |
2023-08-17 |
|
| 3 |
Dragsa 96 Llc |
10 Percent Owner |
2,300,000 |
2022-01-21 |
|
| 4 |
Viking Global Investors Lp |
Officer |
2,300,000 |
2022-01-13 |
|
| 5 |
Milne George M Jr |
Director |
812,881 |
2026-01-14 |
|
| 6 |
Cohen Joshua B |
Co-chief Executive Officer |
373,295 |
2026-03-09 |
|
| 7 |
Klee Justin B. |
Co-chief Executive Officer |
373,295 |
2026-03-09 |
|
| 8 |
Yeramian Patrick D |
Chief Medical Officer |
205,605 |
2024-01-11 |
|
| 9 |
Frates James M |
Chief Financial Officer |
143,985 |
2026-03-09 |
|
| 10 |
Bedrosian Camille L |
Chief Medical Officer |
143,985 |
2026-03-09 |
|
| 11 |
Mazzariello Gina |
Chief Legal Officer |
111,990 |
2026-03-09 |
|
| 12 |
Firestone Karen |
Director |
63,100 |
2025-12-23 |
|
| 13 |
Olinger Margaret |
Chief Commercial Officer |
44,577 |
2023-12-29 |
|
| 14 |
Fonteyne Paul R. |
Director |
25,000 |
2025-06-09 |
|
| 15 |
Zeiher Bernhardt G |
Director |
25,000 |
2025-06-09 |
|
| 16 |
Quimi Daphne |
Director |
25,000 |
2025-06-09 |
|
| 17 |
Cheng Isaac |
Director |
19,000 |
2022-06-10 |
|
Recent Transactions (last 12 months)
| Date |
Name |
Role |
Type |
Shares |
Price |
Value |
| 2026-03-05 |
Mazzariello Gina |
Chief Legal Officer |
RSU Award |
111,990 |
$14.10 |
$1.58M |
| 2026-03-05 |
Cohen Joshua B |
Co-chief Executive Officer |
RSU Award |
373,295 |
$14.10 |
$5.26M |
| 2026-03-05 |
Klee Justin B. |
Co-chief Executive Officer |
RSU Award |
373,295 |
$14.10 |
$5.26M |
| 2026-03-05 |
Bedrosian Camille L |
Chief Medical Officer |
RSU Award |
143,985 |
$14.10 |
$2.03M |
| 2026-03-05 |
Frates James M |
Chief Financial Officer |
RSU Award |
143,985 |
$14.10 |
$2.03M |
| 2026-03-02 |
Mazzariello Gina |
Chief Legal Officer |
Informative Sell |
6,844 |
$14.52 |
$99.38K |
| 2026-03-02 |
Cohen Joshua B |
Co-chief Executive Officer |
Informative Sell |
29,282 |
$14.48 |
$424.12K |
| 2026-03-02 |
Klee Justin B. |
Co-chief Executive Officer |
Informative Sell |
29,282 |
$14.47 |
$423.76K |
| 2026-03-02 |
Bedrosian Camille L |
Chief Medical Officer |
Informative Sell |
6,461 |
$14.58 |
$94.21K |
| 2026-03-02 |
Frates James M |
Chief Financial Officer |
Informative Sell |
7,909 |
$14.52 |
$114.85K |
| 2026-02-23 |
Mazzariello Gina |
Chief Legal Officer |
Informative Sell |
3,419 |
$14.14 |
$48.35K |
| 2026-02-02 |
Mazzariello Gina |
Chief Legal Officer |
Informative Sell |
3,448 |
$14.65 |
$50.52K |
| 2026-02-02 |
Cohen Joshua B |
Co-chief Executive Officer |
Informative Sell |
15,500 |
$14.68 |
$227.59K |
| 2026-02-02 |
Klee Justin B. |
Co-chief Executive Officer |
Informative Sell |
15,500 |
$14.69 |
$227.62K |
| 2026-02-02 |
Frates James M |
Chief Financial Officer |
Informative Sell |
3,557 |
$14.65 |
$52.1K |
| 2026-01-16 |
Cohen Joshua B |
Co-chief Executive Officer |
Option Exercise (Sell) |
2,818 |
$7.57 |
$21.33K |
| 2026-01-15 |
Cohen Joshua B |
Co-chief Executive Officer |
Option Exercise (Sell) |
197,182 |
$7.57 |
$1.49M |
| 2026-01-16 |
Klee Justin B. |
Co-chief Executive Officer |
Option Exercise (Sell) |
2,847 |
$7.57 |
$21.55K |
| 2026-01-15 |
Klee Justin B. |
Co-chief Executive Officer |
Option Exercise (Sell) |
197,153 |
$7.57 |
$1.49M |
| 2026-01-12 |
Milne George M Jr |
Director |
Gift (Given) |
17,780 |
- |
- |
| 2026-01-06 |
Cohen Joshua B |
Co-chief Executive Officer |
Informative Sell |
7,715 |
$11.09 |
$85.6K |
| 2026-01-06 |
Klee Justin B. |
Co-chief Executive Officer |
Informative Sell |
7,715 |
$11.09 |
$85.59K |
| 2026-01-06 |
Frates James M |
Chief Financial Officer |
Informative Sell |
3,326 |
$11.11 |
$36.95K |
| 2025-12-23 |
Firestone Karen |
Director |
Informative Buy |
8,100 |
$12.45 |
$100.85K |
| 2025-12-01 |
Bedrosian Camille L |
Chief Medical Officer |
Informative Sell |
6,580 |
$14.35 |
$94.42K |
