Arrowhead Pharmaceuticals, Inc. (ARWR) has 20 known insider and institutional holders on record. The largest holder is Anzalone Christopher Richard with 3,792,739 shares. Other notable holders include STEWART R BRUCE and Ekchian Leon.
Over the last 12 months, insiders have made 34 transactions in ARWR stock — 10 buys (valued at RSU Award) and 20 sells (valued at $6.2M). Insider selling has exceeded buying during this period.
ARWR Insider Ownership
Top Holder
Anzalone Christopher Richard
3,792,739 shares
Buys (12 mo)
10
$0.00 value
Sells (12 mo)
20
$6.2M value
12-Month Transaction Activity
Top Insider Holders
| # |
Name |
Role |
Shares Owned |
Last Filed |
Relative Size |
| 1 |
Anzalone Christopher Richard |
Chief Executive Officer |
3,792,739 |
2026-01-05 |
|
| 2 |
Stewart R Bruce |
Executive Chairman |
872,000 |
2010-03-08 |
|
| 3 |
Ekchian Leon |
President |
750,000 |
2005-11-21 |
|
| 4 |
Kingsley Joseph Theodore Iii |
Chief Financial Officer |
600,000 |
2007-04-09 |
|
| 5 |
Myszkowski Kenneth Allen |
Chief Financial Officer |
500,600 |
2025-01-07 |
|
| 6 |
Lewis David L. |
Chief Scientific Officer |
472,500 |
2016-01-04 |
|
| 7 |
O'brien Patrick |
COO |
472,408 |
2026-01-08 |
|
| 8 |
Given Bruce D |
Chief Operating Officer |
333,544 |
2020-04-29 |
|
| 9 |
Phillips James M Jr |
Secretary |
300,000 |
2004-04-16 |
|
| 10 |
Hamilton James C |
Chief Medical Officer |
236,958 |
2026-03-09 |
|
| 11 |
Rahn Leroy T |
Director |
225,000 |
2010-03-08 |
|
| 12 |
San Martin Javier |
Chief Medical Officer |
206,800 |
2024-01-08 |
|
| 13 |
Li Zhen |
Snr. VP, Chem and Non-clin Dev |
201,700 |
2019-01-16 |
|
| 14 |
Apel Daniel Joseph |
Chief Financial Officer |
176,200 |
2026-01-08 |
|
| 15 |
Knott David M |
10 Percent Owner |
166,778 |
2007-03-22 |
|
| 16 |
Frykman Edward W |
Director |
148,852 |
2018-01-03 |
|
| 17 |
Oliver Tracie |
Chief Commercial Officer |
127,107 |
2024-07-03 |
|
| 18 |
Given Douglas B |
Director |
124,714 |
2024-12-18 |
|
| 19 |
Perry Michael S |
Director |
123,059 |
2025-12-18 |
|
| 20 |
Hassard James |
Chief Commercial Officer |
105,750 |
2021-06-24 |
|
Recent Transactions (last 12 months)
| Date |
Name |
Role |
Type |
Shares |
Price |
Value |
| 2026-03-05 |
Hamilton James C |
Chief Medical Officer |
Informative Sell |
10,000 |
$64.19 |
$641.9K |
| 2026-01-06 |
Apel Daniel Joseph |
Chief Financial Officer |
RSU Award |
75,000 |
- |
- |
| 2026-01-06 |
Hamilton James C |
Chief Medical Officer |
RSU Award |
75,000 |
- |
- |
| 2026-01-06 |
O'brien Patrick |
COO |
Gift (Given) |
440 |
- |
- |
| 2026-01-05 |
Hamilton James C |
Chief Medical Officer |
Informative Sell |
309 |
$68.00 |
$21.01K |
| 2026-01-05 |
O'brien Patrick |
COO |
Informative Sell |
46 |
$68.00 |
$3.13K |
| 2025-12-31 |
O'brien Patrick |
COO |
Gift (Given) |
560 |
- |
- |
| 2026-01-02 |
Anzalone Christopher Richard |
Chief Executive Officer |
Informative Sell |
5,771 |
$66.39 |
$383.14K |
| 2025-12-26 |
Ferrari Mauro |
Director |
Informative Sell |
7,530 |
$70.00 |
$527.1K |
| 2025-12-29 |
Anzalone Christopher Richard |
Chief Executive Officer |
Option Exercise (Sell) |
16,545 |
$6.15 |
$101.75K |
| 2025-12-19 |
Vakiener Victoria |
Director |
Informative Sell |
1,960 |
$68.39 |
$134.04K |
| 2025-12-19 |
Waddill William D. |
Director |
Informative Sell |
500 |
$68.53 |
$34.27K |
| 2025-12-22 |
Anzalone Christopher Richard |
Chief Executive Officer |
Informative Sell |
2,574 |
$68.85 |
$177.22K |
| 2025-12-19 |
Anzalone Christopher Richard |
Chief Executive Officer |
Informative Sell |
1,319 |
$68.48 |
$90.33K |
| 2025-12-19 |
Olukotun Adeoye Y |
Director |
Informative Sell |
827 |
$68.48 |
$56.63K |
| 2025-12-17 |
Anzalone Christopher Richard |
Chief Executive Officer |
Informative Sell |
1,981 |
$66.30 |
$131.34K |
| 2025-12-16 |
Vakiener Victoria |
Director |
RSU Award |
7,819 |
- |
- |
| 2025-12-16 |
Lu Hongbo |
Director |
RSU Award |
7,819 |
- |
- |
| 2025-12-16 |
Waddill William D. |
Director |
RSU Award |
7,819 |
- |
- |
| 2025-12-16 |
Ferrari Mauro |
Director |
RSU Award |
7,819 |
- |
- |
| 2025-12-16 |
Perry Michael S |
Director |
RSU Award |
7,819 |
- |
- |
| 2025-12-16 |
Olukotun Adeoye Y |
Director |
RSU Award |
7,819 |
- |
- |
| 2025-12-16 |
Ingram Douglas S |
Director |
RSU Award |
7,819 |
- |
- |
| 2025-12-16 |
Anzalone Christopher Richard |
Chief Executive Officer |
Informative Sell |
3,221 |
$67.87 |
$218.61K |
| 2025-12-15 |
Anzalone Christopher Richard |
Chief Executive Officer |
Informative Sell |
8,147 |
$69.96 |
$569.96K |
