Ionis Pharmaceuticals, Inc. (IONS) has 20 known insider and institutional holders on record. The largest holder is Monia Brett P with 254,981 shares. Other notable holders include BENNETT C FRANK and Geary Richard S.
Over the last 12 months, insiders have made 41 transactions in IONS stock — 15 buys (valued at $562.34K) and 14 sells (valued at $12.61M). Insider buying has outpaced selling during this period, which may signal confidence in the company's prospects.
IONS Insider Ownership
Top Holder
Monia Brett P
254,981 shares
Buys (12 mo)
15
$562.34K value
Sells (12 mo)
14
$12.61M value
12-Month Transaction Activity
Top Insider Holders
| # |
Name |
Role |
Shares Owned |
Last Filed |
Relative Size |
| 1 |
Monia Brett P |
Chief Executive Officer |
254,981 |
2026-03-03 |
|
| 2 |
Bennett C Frank |
EVP, Chief Scientific Officer |
100,554 |
2026-03-03 |
|
| 3 |
Geary Richard S |
EVP, Chief Development Officer |
99,492 |
2025-03-04 |
|
| 4 |
Hougen Elizabeth L |
EVP, Finance & CFO |
82,660 |
2026-03-18 |
|
| 5 |
O'neil Patrick R. |
EVP CLO & General Counsel |
72,359 |
2026-03-03 |
|
| 6 |
Birchler Brian |
EVP, Corp and Development Ops |
66,598 |
2026-03-03 |
|
| 7 |
Schneider Eugene |
EVP, Chf Clinical Develop Ofcr |
63,890 |
2026-03-23 |
|
| 8 |
Parshall B Lynne |
Director |
56,344 |
2026-02-13 |
|
| 9 |
Hayden Michael R |
Director |
50,219 |
2025-05-02 |
|
| 10 |
Cadoret-manier Onaiza |
EVP,chf Gl Pdt Str & Oper Ofc |
35,788 |
2024-09-04 |
|
| 11 |
Swayze Eric |
EVP Research |
32,361 |
2026-03-03 |
|
| 12 |
Devers Shannon L. |
EVP, Chief Human Resources Ofc |
16,348 |
2026-04-02 |
|
| 13 |
Jenne Kyle |
EVP, Chf Gl Pdt Str Ofcr |
14,215 |
2025-04-17 |
|
| 14 |
Loscalzo Joseph |
Director |
11,168 |
2026-03-05 |
|
| 15 |
Reikes Peter N |
Director |
10,664 |
2021-10-19 |
|
| 16 |
Klein Joseph Iii |
Director |
8,756 |
2024-07-03 |
|
| 17 |
Muto Frederick T |
Director |
7,110 |
2022-07-19 |
|
| 18 |
Wender Joseph H |
Director |
4,079 |
2024-07-17 |
|
| 19 |
Herman Joan E |
Director |
4,079 |
2024-07-17 |
|
| 20 |
Berthelsen Spencer R |
Director |
4,079 |
2024-07-17 |
|
Recent Transactions (last 12 months)
| Date |
Name |
Role |
Type |
Shares |
Price |
Value |
| 2026-04-02 |
Devers Shannon L. |
EVP, Chief Human Resources Ofc |
Informative Sell |
6,193 |
$74.05 |
$458.61K |
| 2026-04-01 |
Klein Joseph Iii |
Director |
Option Exercise (Sell) |
10,321 |
$41.08 |
$423.99K |
| 2026-03-19 |
Schneider Eugene |
EVP, Chf Clinical Develop Ofcr |
Informative Sell |
5,812 |
$70.97 |
$412.49K |
| 2026-03-17 |
Hougen Elizabeth L |
EVP, Finance & CFO |
Informative Sell |
10,172 |
$73.21 |
$744.66K |
| 2026-03-16 |
Hougen Elizabeth L |
EVP, Finance & CFO |
Option Exercise (Sell) |
33,118 |
$32.60 |
$1.08M |
| 2026-03-03 |
Devers Shannon L. |
EVP, Chief Human Resources Ofc |
Option Exercise (Sell) |
6,951 |
$32.60 |
$226.6K |
| 2026-03-04 |
Baroldi Joseph |
EVP, Chief Business Officer |
Option Exercise (Sell) |
201 |
$32.60 |
$6.55K |
| 2026-03-03 |
Baroldi Joseph |
EVP, Chief Business Officer |
Option Exercise (Sell) |
879 |
$32.60 |
$28.66K |
| 2026-03-03 |
Diaz Allene M. |
Director |
Option Exercise (Sell) |
10,321 |
$41.08 |
$423.99K |
| 2026-03-04 |
Loscalzo Joseph |
Director |
Option Exercise (Sell) |
200 |
$38.06 |
$7.61K |
| 2026-03-03 |
Loscalzo Joseph |
Director |
Option Exercise (Sell) |
832 |
$38.06 |
$31.67K |
| 2026-03-03 |
Klein Joseph Iii |
Director |
Option Exercise (Sell) |
4,000 |
$42.88 |
$171.52K |
| 2026-03-03 |
Bennett C Frank |
EVP, Chief Scientific Officer |
Option Exercise (Sell) |
48,626 |
$60.89 |
$2.96M |
| 2026-02-27 |
Birchler Brian |
EVP, Corp and Development Ops |
Other (Buy) |
351 |
$48.87 |
$17.15K |
| 2026-02-27 |
Swayze Eric |
EVP Research |
Other (Buy) |
256 |
$48.87 |
$12.51K |
| 2026-02-27 |
O'neil Patrick R. |
EVP CLO & General Counsel |
Other (Buy) |
376 |
$48.87 |
$18.37K |
| 2026-02-27 |
Monia Brett P |
Chief Executive Officer |
Other (Buy) |
484 |
$48.87 |
$23.65K |
| 2026-02-27 |
Bennett C Frank |
EVP, Chief Scientific Officer |
Other (Buy) |
261 |
$48.87 |
$12.75K |
| 2026-02-13 |
Swayze Eric |
EVP Research |
Informative Sell |
6,207 |
$82.07 |
$509.4K |
| 2026-02-02 |
Bennett C Frank |
EVP, Chief Scientific Officer |
Other (Sell) |
- |
- |
- |
| 2026-02-11 |
Parshall B Lynne |
Director |
Informative Sell |
5,000 |
$82.72 |
$413.59K |
| 2026-02-06 |
Monia Brett P |
Chief Executive Officer |
Informative Sell |
29,430 |
$85.79 |
$2.52M |
| 2026-02-02 |
Bennett C Frank |
EVP, Chief Scientific Officer |
Option Exercise (Sell) |
48,626 |
$60.89 |
$2.96M |
| 2026-01-29 |
Birchler Brian |
EVP, Corp and Development Ops |
RSU Award |
11,991 |
- |
- |
| 2026-01-30 |
Schneider Eugene |
EVP, Chf Clinical Develop Ofcr |
Informative Sell |
6,179 |
$83.45 |
$515.63K |
