Rhythm Pharmaceuticals, Inc. (RYTM) has 20 known insider and institutional holders on record. The largest holder is RA CAPITAL MANAGEMENT, LLC with 5,422,312 shares. Other notable holders include RA CAPITAL MANAGEMENT, L.P. and THIRD ROCK VENTURES LP.
Over the last 12 months, insiders have made 57 transactions in RYTM stock — 19 buys (valued at $3.32M) and 11 sells (valued at $2.56M). Insider buying has outpaced selling during this period, which may signal confidence in the company's prospects.
RYTM Insider Ownership
Top Holder
RA CAPITAL MANAGEMENT, LLC
5,422,312 shares
Buys (12 mo)
19
$3.32M value
Sells (12 mo)
11
$2.56M value
12-Month Transaction Activity
Top Insider Holders
| # |
Name |
Role |
Shares Owned |
Last Filed |
Relative Size |
| 1 |
Ra Capital Management, Llc |
10 Percent Owner |
5,422,312 |
2019-10-18 |
|
| 2 |
Ra Capital Management, L.p. |
Officer |
4,568,464 |
2020-12-04 |
|
| 3 |
Third Rock Ventures Lp |
10 Percent Owner |
2,981,437 |
2018-09-04 |
|
| 4 |
Orbimed Advisors Llc |
10 Percent Owner |
2,750,079 |
2018-05-24 |
|
| 5 |
Foley Todd |
Director |
909,258 |
2021-03-16 |
|
| 6 |
Gottesdiener Keith Michael |
CEO & President |
207,877 |
2020-03-11 |
|
| 7 |
Smith Hunter C |
Chief Financial Officer |
91,401 |
2026-03-02 |
|
| 8 |
Meeker David P |
President and CEO |
71,900 |
2026-02-13 |
|
| 9 |
Desikan Nithya |
Chief Commercial Officer |
43,602 |
2020-09-01 |
|
| 10 |
Fiedorek Fred T. |
Chief Medical Officer |
25,000 |
2018-02-16 |
|
| 11 |
Lee Jennifer Kayden |
EVP, Head of North America |
21,650 |
2026-02-13 |
|
| 12 |
Garfield Alastair |
Chief Scientific Officer |
16,650 |
2026-02-13 |
|
| 13 |
Shulman Joseph |
Chief Technical Officer |
15,000 |
2026-02-13 |
|
| 14 |
Mathers Edward T |
Director |
14,168 |
2026-03-16 |
|
| 15 |
Van Der Ploeg Leonardus H.t. |
Chief Scientific Officer |
13,611 |
2019-06-03 |
|
| 16 |
Manning Linda Shapiro |
Chief Medical Officer |
12,500 |
2022-02-11 |
|
| 17 |
Cramer Pamela J. |
Chief Human Resources Officer |
11,650 |
2026-02-13 |
|
| 18 |
Exter Neil |
Director |
10,000 |
2018-06-08 |
|
| 19 |
Stewart Murray |
Chief Medical Officer |
9,375 |
2021-02-16 |
|
| 20 |
Popovits Kimberly J |
Director |
6,808 |
2026-04-03 |
|
Recent Transactions (last 12 months)
| Date |
Name |
Role |
Type |
Shares |
Price |
Value |
| 2026-04-01 |
Mazabraud Yann |
EVP, Head of International |
Option Exercise (Sell) |
2,500 |
- |
- |
| 2026-04-01 |
Popovits Kimberly J |
Director |
RSU Award |
6,808 |
- |
- |
| 2026-04-01 |
Popovits Kimberly J |
Director |
Unknown |
- |
- |
- |
| 2026-03-12 |
Mathers Edward T |
Director |
Other (Buy) |
4,199 |
- |
- |
| 2026-03-04 |
German Christopher Paul |
Corporate Controller & CAO |
Informative Sell |
5,614 |
$89.56 |
$502.79K |
| 2026-03-02 |
Mazabraud Yann |
EVP, Head of International |
RSU Award |
35,000 |
$94.94 |
$3.32M |
| 2026-03-02 |
Mathers Edward T |
Director |
Other (Buy) |
4,198 |
- |
- |
| 2026-03-01 |
German Christopher Paul |
Corporate Controller & CAO |
Option Exercise (Sell) |
1,162 |
- |
- |
| 2026-03-02 |
Smith Hunter C |
Chief Financial Officer |
Option Exercise (Sell) |
6,099 |
$6.80 |
$41.47K |
| 2026-02-19 |
Smith Hunter C |
Chief Financial Officer |
Informative Sell |
585 |
$103.28 |
$60.42K |
| 2026-02-17 |
Smith Hunter C |
Chief Financial Officer |
Informative Sell |
200 |
$103.84 |
$20.77K |
| 2026-02-14 |
Mazabraud Yann |
EVP, Head of International |
Option Exercise (Sell) |
10,000 |
- |
- |
| 2026-02-11 |
Garfield Alastair |
Chief Scientific Officer |
RSU Award |
16,650 |
- |
- |
| 2026-02-11 |
Shulman Joseph |
Chief Technical Officer |
RSU Award |
15,000 |
- |
- |
| 2026-02-11 |
Cramer Pamela J. |
Chief Human Resources Officer |
RSU Award |
11,650 |
- |
- |
| 2026-02-11 |
Lee Jennifer Kayden |
EVP, Head of North America |
RSU Award |
21,650 |
- |
- |
| 2026-02-11 |
Mazabraud Yann |
EVP, Head of International |
RSU Award |
23,350 |
- |
- |
| 2026-02-11 |
Meeker David P |
President and CEO |
RSU Award |
71,900 |
- |
- |
| 2026-02-11 |
German Christopher Paul |
Corporate Controller & CAO |
RSU Award |
5,215 |
- |
- |
| 2026-02-12 |
Smith Hunter C |
Chief Financial Officer |
Informative Sell |
100 |
$100.10 |
$10.01K |
| 2026-02-11 |
Smith Hunter C |
Chief Financial Officer |
RSU Award |
25,000 |
- |
- |
| 2026-02-10 |
Smith Hunter C |
Chief Financial Officer |
Informative Sell |
100 |
$104.76 |
$10.48K |
| 2026-02-05 |
Smith Hunter C |
Chief Financial Officer |
Informative Sell |
3,381 |
$106.06 |
$358.6K |
| 2026-02-04 |
Smith Hunter C |
Chief Financial Officer |
Informative Sell |
747 |
$107.67 |
$80.43K |
| 2026-02-01 |
Garfield Alastair |
Chief Scientific Officer |
Tax Withholding of RSU |
2,026 |
$108.99 |
$220.81K |
