Vertex Pharmaceuticals Incorporated (VRTX) has 20 known insider and institutional holders on record. The largest holder is Arbuckle Stuart A with 100,611 shares. Other notable holders include Kewalramani Reshma and Sachdev Amit.
Over the last 12 months, insiders have made 71 transactions in VRTX stock — 11 buys (valued at $3.62M) and 31 sells (valued at $19.14M). Insider selling has exceeded buying during this period.
VRTX Insider Ownership
Top Holder
Arbuckle Stuart A
100,611 shares
Buys (12 mo)
11
$3.62M value
Sells (12 mo)
31
$19.14M value
12-Month Transaction Activity
Top Insider Holders
| # |
Name |
Role |
Shares Owned |
Last Filed |
Relative Size |
| 1 |
Arbuckle Stuart A |
EVP, COO |
100,611 |
2025-05-15 |
|
| 2 |
Kewalramani Reshma |
CEO & President |
98,278 |
2026-03-03 |
|
| 3 |
Sachdev Amit |
EVP Chief Patient & Ext Af Off |
57,416 |
2026-02-26 |
|
| 4 |
Wagner Charles F Jr |
EVP, Co & Fo |
47,042 |
2026-02-26 |
|
| 5 |
Tatsis Ourania |
EVP, Chief Reg. & Quality Off. |
47,023 |
2026-02-26 |
|
| 6 |
Sanna Bastiano |
EVP, Cell & Genetic Therapies |
34,888 |
2023-05-09 |
|
| 7 |
Leiden Jeffrey M |
Executive Chairman |
34,797 |
2026-02-26 |
|
| 8 |
Parini Michael |
EVP, Chief Adm, Leg & Bd Off |
33,865 |
2021-02-26 |
|
| 9 |
Bozic Carmen |
EVP and CMO |
33,076 |
2026-03-31 |
|
| 10 |
Altshuler David |
EVP, Chief Scientific Officer |
23,281 |
2025-05-19 |
|
| 11 |
Liu Joy |
EVP and Chief Legal Officer |
21,833 |
2026-04-03 |
|
| 12 |
Atkinson Edward Morrow Iii |
EVP, Chief Technical Ops. Off. |
19,100 |
2026-02-26 |
|
| 13 |
Biller Jonathan |
EVP and Chief Legal Officer |
14,604 |
2026-02-26 |
|
| 14 |
Silva Paul M |
SVP & Chief Accounting Officer |
12,666 |
2021-03-02 |
|
| 15 |
Mckechnie Duncan |
EVP, Chief Commercial Officer |
12,489 |
2026-03-13 |
|
| 16 |
Bunnage Mark E. |
EVP, Chief Scientific Officer |
7,904 |
2026-02-26 |
|
| 17 |
Carney Lloyd |
Director |
7,115 |
2025-05-05 |
|
| 18 |
Ambrose Kristen |
SVP & Chief Accounting Officer |
6,624 |
2026-03-02 |
|
| 19 |
Bhatia Sangeeta N. |
Director |
4,299 |
2026-02-18 |
|
| 20 |
Lee Yuchun |
Director |
3,481 |
2023-05-03 |
|
Recent Transactions (last 12 months)
| Date |
Name |
Role |
Type |
Shares |
Price |
Value |
| 2026-04-01 |
Liu Joy |
EVP and Chief Legal Officer |
Informative Sell |
978 |
$449.17 |
$439.29K |
| 2026-03-27 |
Bozic Carmen |
EVP and CMO |
Informative Sell |
2,329 |
$450.95 |
$1.05M |
| 2026-03-13 |
Bozic Carmen |
EVP and CMO |
Informative Sell |
2,329 |
$481.79 |
$1.12M |
| 2026-03-11 |
Mckechnie Duncan |
EVP, Chief Commercial Officer |
Informative Sell |
2,633 |
$498.42 |
$1.31M |
| 2026-03-04 |
Mckechnie Duncan |
EVP, Chief Commercial Officer |
Informative Sell |
2,437 |
$475.30 |
$1.16M |
| 2026-03-02 |
Liu Joy |
EVP and Chief Legal Officer |
Informative Sell |
892 |
$495.96 |
$442.4K |
| 2026-03-01 |
Liu Joy |
EVP and Chief Legal Officer |
Unknown |
7,044 |
$155.57 |
$1.1M |
| 2026-02-27 |
Bozic Carmen |
EVP and CMO |
Informative Sell |
2,329 |
$480.31 |
$1.12M |
| 2026-02-27 |
Kewalramani Reshma |
CEO & President |
Informative Sell |
1,725 |
$496.95 |
$857.24K |
| 2026-02-26 |
Ambrose Kristen |
SVP & Chief Accounting Officer |
Informative Sell |
357 |
$483.36 |
$172.56K |
| 2026-02-25 |
Bunnage Mark E. |
EVP, Chief Scientific Officer |
Informative Sell |
620 |
$486.35 |
$301.54K |
| 2026-02-24 |
Bunnage Mark E. |
EVP, Chief Scientific Officer |
Tax Withholding of RSU |
582 |
$485.11 |
$282.33K |
| 2026-02-25 |
Mckechnie Duncan |
EVP, Chief Commercial Officer |
Informative Sell |
2,410 |
$489.00 |
$1.18M |
| 2026-02-24 |
Mckechnie Duncan |
EVP, Chief Commercial Officer |
Tax Withholding of RSU |
873 |
$485.11 |
$423.5K |
| 2026-02-25 |
Atkinson Edward Morrow Iii |
EVP, Chief Technical Ops. Off. |
Informative Sell |
668 |
$486.35 |
$324.88K |
| 2026-02-24 |
Atkinson Edward Morrow Iii |
EVP, Chief Technical Ops. Off. |
Tax Withholding of RSU |
1,627 |
$485.11 |
$789.27K |
| 2026-02-25 |
Ambrose Kristen |
SVP & Chief Accounting Officer |
Informative Sell |
223 |
$486.35 |
$108.46K |
| 2026-02-24 |
Ambrose Kristen |
SVP & Chief Accounting Officer |
Tax Withholding of RSU |
546 |
$485.11 |
$264.87K |
| 2026-02-24 |
Bozic Carmen |
EVP and CMO |
Tax Withholding of RSU |
1,453 |
$485.11 |
$704.86K |
| 2026-02-25 |
Tatsis Ourania |
EVP, Chief Reg. & Quality Off. |
Informative Sell |
260 |
$486.35 |
$126.45K |
| 2026-02-24 |
Tatsis Ourania |
EVP, Chief Reg. & Quality Off. |
Tax Withholding of RSU |
1,627 |
$485.11 |
$789.27K |
| 2026-02-25 |
Biller Jonathan |
EVP and Chief Legal Officer |
Informative Sell |
945 |
$486.35 |
$459.6K |
| 2026-02-24 |
Biller Jonathan |
EVP and Chief Legal Officer |
Tax Withholding of RSU |
1,144 |
$485.11 |
$554.97K |
| 2026-02-24 |
Kewalramani Reshma |
CEO & President |
Tax Withholding of RSU |
4,981 |
$485.11 |
$2.42M |
| 2026-02-25 |
Sachdev Amit |
EVP Chief Patient & Ext Af Off |
Informative Sell |
1,846 |
$486.35 |
$897.8K |
