Xilio Therapeutics, Inc. (XLO) has 20 known insider and institutional holders on record. The largest holder is GILEAD SCIENCES, INC. with 40,384,266 shares. Other notable holders include Chudnovsky Yekaterina and Bain Capital Life Sciences Investors, LLC.
Over the last 12 months, insiders have made 34 transactions in XLO stock — 24 buys (valued at $12.81M) and 2 sells (valued at $5.7K). Insider buying has outpaced selling during this period, which may signal confidence in the company's prospects.
XLO Insider Ownership
Top Holder
GILEAD SCIENCES, INC.
40,384,266 shares
Buys (12 mo)
24
$12.81M value
Sells (12 mo)
2
$5.7K value
12-Month Transaction Activity
Top Insider Holders
| # |
Name |
Role |
Shares Owned |
Last Filed |
Relative Size |
| 1 |
Gilead Sciences, Inc. |
10 Percent Owner |
40,384,266 |
2026-02-17 |
|
| 2 |
Chudnovsky Yekaterina |
10 Percent Owner |
7,000,000 |
2024-09-27 |
|
| 3 |
Bain Capital Life Sciences Investors, Llc |
10 Percent Owner |
2,776,402 |
2021-12-10 |
|
| 4 |
Russo Rene |
President and CEO |
1,500,258 |
2026-01-05 |
|
| 5 |
Atlas Venture Fund Xi, L.p. |
10 Percent Owner |
734,546 |
2024-02-09 |
|
| 6 |
Frankenfield Christopher James |
Chief Financial Officer |
668,789 |
2026-01-05 |
|
| 7 |
Luptakova Katarina |
Chief Medical Officer |
451,885 |
2026-01-05 |
|
| 8 |
Huber Martin H. Jr. |
President and Head of R&d |
136,500 |
2023-08-18 |
|
| 9 |
Tomlinson Simon M |
10 Percent Owner |
131,117 |
2021-10-21 |
|
| 10 |
Estate Of Ulrich Rodeck |
10 Percent Owner |
100,080 |
2021-10-21 |
|
| 11 |
Williams John Charles |
10 Percent Owner |
100,080 |
2021-10-22 |
|
| 12 |
Brennan Kevin M. |
SVP, Finance and Accounting |
95,221 |
2026-01-05 |
|
| 13 |
Bello Akintunde Olatokumbo |
Director |
62,000 |
2025-06-12 |
|
| 14 |
Giovine Salvatore |
Chief Financial Officer |
49,500 |
2022-02-24 |
|
| 15 |
Ross Robert W. |
Director |
31,000 |
2025-06-12 |
|
| 16 |
Clancy Paul J |
Director |
31,000 |
2025-06-12 |
|
| 17 |
Brennan Aoife |
Director |
31,000 |
2025-06-12 |
|
| 18 |
Bonstein Sara |
Director |
31,000 |
2025-06-12 |
|
| 19 |
Rossi Christina |
Director |
31,000 |
2025-06-12 |
|
| 20 |
Curran Daniel J. |
Director |
31,000 |
2025-06-12 |
|
Recent Transactions (last 12 months)
| Date |
Name |
Role |
Type |
Shares |
Price |
Value |
| 2026-03-26 |
Shannon James Samuel |
Director |
Informative Buy |
5,000 |
$8.79 |
$43.95K |
| 2026-02-13 |
Gilead Sciences, Inc. |
10 Percent Owner |
Informative Buy |
3,739,000 |
$0.00 |
$373.90 |
| 2026-01-01 |
Luptakova Katarina |
Chief Medical Officer |
Option Exercise |
16,625 |
- |
- |
| 2025-12-31 |
Luptakova Katarina |
Chief Medical Officer |
RSU Award |
451,885 |
$0.84 |
$380.04K |
| 2026-01-02 |
Frankenfield Christopher James |
Chief Financial Officer |
Informative Sell |
7,030 |
$0.64 |
$4.52K |
| 2026-01-01 |
Frankenfield Christopher James |
Chief Financial Officer |
Option Exercise |
19,375 |
- |
- |
| 2025-12-31 |
Frankenfield Christopher James |
Chief Financial Officer |
RSU Award |
668,789 |
$0.84 |
$562.45K |
| 2026-01-02 |
Brennan Kevin M. |
SVP, Finance and Accounting |
Informative Sell |
1,826 |
$0.64 |
$1.17K |
| 2026-01-01 |
Brennan Kevin M. |
SVP, Finance and Accounting |
Option Exercise |
5,000 |
- |
- |
| 2025-12-31 |
Brennan Kevin M. |
SVP, Finance and Accounting |
RSU Award |
95,221 |
$0.84 |
$80.08K |
| 2026-01-01 |
Russo Rene |
President and CEO |
Option Exercise (Sell) |
44,250 |
- |
- |
| 2025-12-31 |
Russo Rene |
President and CEO |
RSU Award |
1,500,258 |
$0.84 |
$1.26M |
| 2025-11-26 |
Gilead Sciences, Inc. |
10 Percent Owner |
Option Exercise (ITM) |
13,335,000 |
$0.75 |
$10M |
| 2025-11-21 |
Luptakova Katarina |
Chief Medical Officer |
Return of Shares |
25,000 |
$2.79 |
$69.63K |
| 2025-11-21 |
Frankenfield Christopher James |
Chief Financial Officer |
Return of Shares |
150,000 |
$2.75 |
$412.5K |
| 2025-11-21 |
Brennan Kevin M. |
SVP, Finance and Accounting |
Return of Shares |
20,000 |
$1.08 |
$21.6K |
| 2025-11-21 |
Russo Rene |
President and CEO |
Return of Shares |
135,134 |
$11.69 |
$1.58M |
| 2025-06-16 |
Russo Rene |
President and CEO |
Informative Buy |
36,289 |
$0.68 |
$24.68K |
| 2025-01-01 |
Russo Rene |
Officer |
Unknown |
- |
- |
- |
| 2025-06-17 |
Shannon James Samuel |
Director |
Informative Buy |
25,000 |
$0.69 |
$17.22K |
| 2025-06-16 |
Shannon James Samuel |
Director |
Informative Buy |
45,000 |
$0.69 |
$30.87K |
| 2025-06-10 |
Bello Akintunde Olatokumbo |
Director |
RSU Award |
62,000 |
$0.70 |
$43.4K |
| 2025-06-10 |
Bello Akintunde Olatokumbo |
Officer |
Unknown |
- |
- |
- |
| 2025-06-11 |
Curran Daniel J. |
Director |
RSU Award |
31,000 |
$0.69 |
$21.48K |
| 2025-06-11 |
Xu Yuan |
Director |
RSU Award |
31,000 |
$0.69 |
$21.48K |
