Ionis Pharmaceuticals, Inc. IONS NASDAQ

NASDAQ Global Select • Healthcare • Biotechnology • US • USD

SharesGrow Score

46/100

3/7 Pass

SharesGrow Intrinsic Value

There have been 50 recent insider transactions recorded for Ionis Pharmaceuticals, Inc. (IONS), including 21 buys and 29 sells. Total insider buying was valued at $634.42K and total insider selling at $22.21M.

Notable insiders with recent activity include Devers Shannon L., Klein Joseph Iii, Schneider Eugene. Insider transactions can provide insights into how company leadership views the stock's valuation and future prospects.

Insider Transactions — IONS

Date	Name	Role	Transaction	Shares	Avg. Price	Value	Shares Owned
2026-04-02	Devers Shannon L.	EVP, Chief Human Resources Ofc	Informative Sell	6,193	$74.05	$458.61K	16,348
2026-04-01	Klein Joseph Iii	Director	Option Exercise (Sell)	10,321	$41.08	$423.99K	-
2026-03-19	Schneider Eugene	EVP, Chf Clinical Develop Ofcr	Informative Sell	5,812	$70.97	$412.49K	63,890
2026-03-17	Hougen Elizabeth L	EVP, Finance & CFO	Informative Sell	10,172	$73.21	$744.66K	82,660
2026-03-16	Hougen Elizabeth L	EVP, Finance & CFO	Option Exercise (Sell)	33,118	$32.60	$1.08M	-
2026-03-04	Loscalzo Joseph	Director	Option Exercise (Sell)	200	$38.06	$7.61K	10,968
2026-03-04	Baroldi Joseph	EVP, Chief Business Officer	Option Exercise (Sell)	201	$32.60	$6.55K	1,769
2026-03-03	Bennett C Frank	EVP, Chief Scientific Officer	Option Exercise (Sell)	48,626	$60.89	$2.96M	-
2026-03-03	Klein Joseph Iii	Director	Option Exercise (Sell)	4,000	$42.88	$171.52K	-
2026-03-03	Loscalzo Joseph	Director	Option Exercise (Sell)	832	$38.06	$31.67K	11,168
2026-03-03	Diaz Allene M.	Director	Option Exercise (Sell)	10,321	$41.08	$423.99K	-
2026-03-03	Baroldi Joseph	EVP, Chief Business Officer	Option Exercise (Sell)	879	$32.60	$28.66K	1,970
2026-03-03	Devers Shannon L.	EVP, Chief Human Resources Ofc	Option Exercise (Sell)	6,951	$32.60	$226.6K	928
2026-02-27	Bennett C Frank	EVP, Chief Scientific Officer	Other (Buy)	261	$48.87	$12.75K	100,554
2026-02-27	Monia Brett P	Chief Executive Officer	Other (Buy)	484	$48.87	$23.65K	254,981
2026-02-27	O'neil Patrick R.	EVP CLO & General Counsel	Other (Buy)	376	$48.87	$18.37K	72,359
2026-02-27	Swayze Eric	EVP Research	Other (Buy)	256	$48.87	$12.51K	32,361
2026-02-27	Birchler Brian	EVP, Corp and Development Ops	Other (Buy)	351	$48.87	$17.15K	66,598
2026-02-13	Swayze Eric	EVP Research	Informative Sell	6,207	$82.07	$509.4K	32,105
2026-02-11	Parshall B Lynne	Director	Informative Sell	5,000	$82.72	$413.59K	56,344
2026-02-06	Monia Brett P	Chief Executive Officer	Informative Sell	29,430	$85.79	$2.52M	254,497
2026-02-02	Bennett C Frank	EVP, Chief Scientific Officer	Option Exercise (Sell)	48,626	$60.89	$2.96M	-
2026-02-02	Bennett C Frank	EVP, Chief Scientific Officer	Other (Sell)	-	-	-	100,293
2026-01-30	Hougen Elizabeth L	EVP, Finance & CFO	Informative Sell	6,988	$83.24	$581.7K	132,881
2026-01-30	Monia Brett P	Chief Executive Officer	Informative Sell	62,970	$82.72	$5.21M	283,927
2026-01-30	O'neil Patrick R.	EVP CLO & General Counsel	Informative Sell	6,179	$83.53	$516.15K	71,983
2026-01-30	Swayze Eric	EVP Research	Informative Sell	6,179	$82.93	$512.45K	47,747
2026-01-30	Schneider Eugene	EVP, Chf Clinical Develop Ofcr	Informative Sell	6,179	$83.45	$515.63K	69,702
2026-01-29	Hougen Elizabeth L	EVP, Finance & CFO	RSU Award	13,562	-	-	139,869
2026-01-29	Monia Brett P	Chief Executive Officer	RSU Award	122,214	-	-	346,897
2026-01-29	O'neil Patrick R.	EVP CLO & General Counsel	RSU Award	11,991	-	-	78,162
2026-01-29	Swayze Eric	EVP Research	RSU Award	11,991	-	-	53,926
2026-01-29	Schneider Eugene	EVP, Chf Clinical Develop Ofcr	RSU Award	11,991	-	-	75,881
2026-01-29	Birchler Brian	EVP, Corp and Development Ops	RSU Award	11,991	-	-	72,426
2025-05-01	Hayden Michael R	Director	Informative Buy	15,000	$31.86	$477.9K	50,219
2025-04-16	Jenne Kyle	EVP, Chf Gl Pdt Str Ofcr	Informative Sell	3,016	$28.36	$85.53K	11,199
2025-04-16	Baroldi Joseph	EVP, Chief Business Officer	Informative Sell	3,928	$28.40	$111.56K	31,926
2025-04-16	Birchler Brian	EVP, Corp and Development Ops	Informative Sell	680	$28.37	$19.29K	56,660
2025-04-15	Jenne Kyle	EVP, Chf Gl Pdt Str Ofcr	Option Exercise	12,226	-	-	14,215
2025-04-15	Baroldi Joseph	EVP, Chief Business Officer	Option Exercise	10,837	-	-	35,854
2025-04-15	Birchler Brian	EVP, Corp and Development Ops	Option Exercise	1,875	-	-	57,340
2025-03-11	Monia Brett P	Chief Executive Officer	Informative Sell	140	$32.32	$4.52K	180,980
2025-02-28	Bennett C Frank	EVP, Chief Scientific Officer	Other (Buy)	320	$28.21	$9.03K	93,466
2025-02-28	Geary Richard S	EVP, Chief Development Officer	Other (Buy)	415	$28.21	$11.71K	99,492
2025-02-28	Monia Brett P	Chief Executive Officer	Other (Buy)	437	$28.21	$12.33K	181,120
2025-02-28	O'neil Patrick R.	EVP CLO & General Counsel	Other (Buy)	554	$28.21	$15.63K	56,799
2025-02-28	Swayze Eric	EVP Research	Other (Buy)	415	$28.21	$11.71K	48,432
2025-02-28	Birchler Brian	EVP, Corp and Development Ops	Other (Buy)	414	$28.21	$11.68K	55,465
2025-02-20	O'neil Patrick R.	EVP CLO & General Counsel	Informative Sell	1,207	$32.35	$39.05K	56,245
2025-02-04	Monia Brett P	Chief Executive Officer	Informative Sell	38,843	$31.65	$1.23M	180,683

■ Informative Buy/Sell — open market transaction (most significant) ■ Uninformative Buy — award, option exercise, conversion ■ Uninformative Sell — tax withholding, award vest sale ■ Neutral — gift, trust, expiry