Denali Therapeutics Inc. (DNLI) has 20 known insider and institutional holders on record. The largest holder is BIOGEN INC. with 13,310,243 shares. Other notable holders include ARCH Venture Fund VIII, L.P. and BRATTON DOUGLAS K.
Over the last 12 months, insiders have made 23 transactions in DNLI stock — 12 buys (valued at $8.38M) and 5 sells (valued at $956.43K). Insider buying has outpaced selling during this period, which may signal confidence in the company's prospects.
DNLI Insider Ownership
Top Holder
BIOGEN INC.
13,310,243 shares
Buys (12 mo)
12
$8.38M value
Sells (12 mo)
5
$956.43K value
12-Month Transaction Activity
Top Insider Holders
| # |
Name |
Role |
Shares Owned |
Last Filed |
Relative Size |
| 1 |
Biogen Inc. |
10 Percent Owner |
13,310,243 |
2020-09-28 |
|
| 2 |
Arch Venture Fund Viii, L.p. |
10 Percent Owner |
10,668,749 |
2019-08-12 |
|
| 3 |
Bratton Douglas K |
10 Percent Owner |
9,984,836 |
2021-02-17 |
|
| 4 |
Baker Bros. Advisors Lp |
Director |
2,335,469 |
2025-12-15 |
|
| 5 |
Watts Ryan J. |
President and CEO |
296,833 |
2026-01-08 |
|
| 6 |
Schuth Alexander O. |
Cofo and Secretary |
282,828 |
2026-01-08 |
|
| 7 |
Ho Carole |
Chief Medical Officer |
217,391 |
2025-08-14 |
|
| 8 |
Sato Vicki L |
Director |
107,976 |
2025-01-03 |
|
| 9 |
Fmr Llc |
10 Percent Owner |
33,215 |
2017-12-22 |
|
| 10 |
Cook Jennifer E. |
Director |
18,111 |
2025-06-05 |
|
| 11 |
Klein Peter S |
Director |
18,111 |
2025-06-05 |
|
| 12 |
Thornberry Nancy |
Director |
18,111 |
2025-06-05 |
|
| 13 |
Krognes Steve E. |
Director |
18,111 |
2025-06-05 |
|
| 14 |
Tessier-lavigne Marc |
Director |
18,111 |
2025-06-05 |
|
| 15 |
Harris Erik |
Director |
17,052 |
2024-06-04 |
|
| 16 |
Flatley Jay T |
Director |
16,220 |
2025-06-05 |
|
| 17 |
Schenkein David P |
Director |
15,257 |
2025-06-05 |
|
| 18 |
Cole Douglas G. |
Director |
12,649 |
2023-06-05 |
|
| 19 |
Van Hauwermeiren Timothy |
Director |
10,632 |
2025-11-06 |
|
| 20 |
Nelsen Robert |
Director |
6,222 |
2021-06-04 |
|
Recent Transactions (last 12 months)
| Date |
Name |
Role |
Type |
Shares |
Price |
Value |
| 2026-01-06 |
Schuth Alexander O. |
Cofo and Secretary |
Informative Sell |
17,218 |
$16.50 |
$284.1K |
| 2026-01-06 |
Watts Ryan J. |
President and CEO |
Informative Sell |
35,198 |
$16.50 |
$580.77K |
| 2026-01-03 |
Schuth Alexander O. |
Cofo and Secretary |
RSU Award |
173,100 |
$16.27 |
$2.82M |
| 2026-01-03 |
Watts Ryan J. |
President and CEO |
RSU Award |
236,880 |
$16.27 |
$3.85M |
| 2025-12-11 |
Baker Bros. Advisors Lp |
Director |
Informative Buy |
190,523 |
$0.01 |
$1.91K |
| 2025-11-04 |
Van Hauwermeiren Timothy |
Director |
RSU Award |
10,632 |
- |
- |
| 2025-11-04 |
Van Hauwermeiren Timothy |
Director |
Unknown |
- |
- |
- |
| 2025-09-03 |
Watts Ryan J. |
President and CEO |
Gift (Given) |
50,000 |
- |
- |
| 2025-08-13 |
Ho Carole |
Chief Medical Officer |
Informative Sell |
806 |
$14.64 |
$11.8K |
| 2025-08-12 |
Ho Carole |
Chief Medical Officer |
Informative Sell |
2,937 |
$13.58 |
$39.88K |
| 2025-08-12 |
Schuth Alexander O. |
Cofo and Secretary |
Informative Sell |
2,937 |
$13.58 |
$39.88K |
| 2025-08-05 |
Ho Carole |
Chief Medical Officer |
Option Exercise (Sell) |
44,655 |
$0.68 |
$30.37K |
| 2025-07-09 |
Watts Ryan J. |
President and CEO |
Option Exercise (Sell) |
40,000 |
$5.28 |
$211.2K |
| 2025-06-03 |
Thornberry Nancy |
Director |
RSU Award |
18,111 |
$13.93 |
$252.29K |
| 2025-06-03 |
Cook Jennifer E. |
Director |
RSU Award |
18,111 |
$13.93 |
$252.29K |
| 2025-06-03 |
Krognes Steve E. |
Director |
RSU Award |
18,111 |
$13.93 |
$252.29K |
| 2025-06-03 |
Schenkein David P |
Director |
RSU Award |
6,037 |
- |
- |
| 2025-06-03 |
Klein Peter S |
Director |
RSU Award |
18,111 |
$13.93 |
$252.29K |
| 2025-06-03 |
Tessier-lavigne Marc |
Director |
RSU Award |
18,111 |
$13.93 |
$252.29K |
| 2025-06-03 |
Baker Bros. Advisors Lp |
Director |
RSU Award |
31,695 |
$13.93 |
$441.51K |
| 2025-06-03 |
Baker Bros. Advisors Lp |
Director |
Unknown |
23,901,119 |
$0.01 |
$239.01K |
| 2025-06-03 |
Flatley Jay T |
Director |
RSU Award |
6,037 |
- |
- |
| 2025-06-03 |
Baker Julian |
Officer |
Unknown |
- |
- |
- |
