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Denali Therapeutics Inc. DNLI NASDAQ

NASDAQ Global Select • Healthcare • Biotechnology • US • USD

SharesGrow Score
62/100
2/6 Pass
SharesGrow Intrinsic Value
N/A
Negative cash flow
Analyst Price Target
$34.40
+70.6%
SharesGrow 7-Criteria Score All 7 criteria scored · valuation-related highlighted on this page

Denali Therapeutics Inc. (DNLI) has a negative trailing P/E of -6.7, meaning the company is currently unprofitable on a trailing twelve-month (TTM) basis. The forward P/E of 14.4 based on analyst estimates suggests a return to profitability is expected. Trailing earnings yield is -15.03%, forward earnings yield 6.93%.

Criteria proven by this page:

  • VALUE (58/100, Partial) — mixed signals — some valuation metrics are favorable while others are stretched.
  • Forward P/E 14.4 — analysts expect a return to profitability with estimated EPS of $1.40 for FY2030.
  • Trailing Earnings Yield -15.03% — negative yield confirms the company is currently unprofitable. Investors are paying for a turnaround rather than current earnings. Forward yield improves to 6.93% as earnings recover.
  • Analyst consensus target $34.40 (+70.6% upside) — significant upside potential according to Wall Street analysts.

Overall SharesGrow Score: 61/100 with 2/7 criteria passed.

SharesGrow 7-Criteria Score
62/100
SG Score
View full scorecard →
~
VALUE
58/100
Price-to-Earnings & upside
Proven by this page
FUTURE
100/100
Analyst consensus
→ Forecast
PAST
0/100
→ Income
HEALTH
100/100
Debt-to-Equity & liquidity
→ Health
~
MOAT
58/100
→ Income
~
GROWTH
58/100
→ Income
INCOME
N/A
No coverage

Valuation Snapshot — DNLI

Valuation Multiples
P/E (TTM)-6.7
Forward P/E14.4
PEG RatioN/A
Forward PEGN/A
P/B Ratio3.36
P/S Ratio0.00
EV/EBITDA-5.5
Per Share Data
EPS (TTM)$-2.92
Forward EPS (Est.)$1.40
Book Value / Share$5.78
Revenue / Share$0.00
FCF / Share$-2.41
Yields & Fair Value
Earnings Yield-15.03%
Forward Earnings Yield6.93%
Dividend Yield0.00%
Analyst Target$34.40 (+70.6%)

Historical Valuation

Year P/E (TTM) PEG Ratio P/B Ratio P/S Ratio Dividend Yield
2016 -1.6 -0.01 0.54 0.00 -
2017 -2.7 0.05 0.50 0.00 -
2018 -52.8 0.57 3.50 14.82 -
2019 -8.4 -0.02 4.22 62.43 -
2020 128.3 -0.98 7.93 27.19 -
2021 -18.7 0.04 5.63 111.38 -
2022 -10.7 -1.22 3.35 32.19 -
2023 -20.3 0.34 2.86 8.92 -
2024 -7.9 -0.06 2.73 0.00 -
2025 -5.7 -0.36 2.86 0.00 -

EPS: Actual vs Estimates

P/E Ratio & Earnings Yield

Earnings Per Share (EPS) History

Year EPS (Diluted) Revenue Net Income Net Margin
2016 $-13.49 $0.00 $-86.65M -
2017 $-5.89 $0.00 $-88.19M -
2018 $-0.39 $129.16M $-36.24M -28.1%
2019 $-2.07 $26.68M $-197.61M -740.7%
2020 $0.63 $335.66M $71.14M 21.2%
2021 $-2.39 $48.66M $-290.58M -597.2%
2022 $-2.60 $108.46M $-325.99M -300.6%
2023 $-1.06 $330.53M $-145.22M -43.9%
2024 $-2.57 $0.00 $-422.77M -
2025 $-2.97 $0.00 $-512.54M -

Analyst Estimates

Year EPS (Avg) EPS Range Revenue (Avg) Revenue Range Analysts
2026 $-2.58 $-2.93 – $-2.05 $58.31M $5.45M – $172.7M 15
2027 $-2.49 $-3.10 – $-1.38 $136.77M $19.07M – $282.01M 14
2028 $-0.75 $-2.23 – $1.34 $494.44M $485.11M – $503.76M 14
2029 $0.14 $-0.02 – $0.39 $689.88M $101.99M – $1.65B 8
2030 $1.68 $-0.18 – $4.71 $1.06B $156.07M – $2.52B 12
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