Praxis Precision Medicines, Inc. PRAX NASDAQ

NASDAQ Global Select • Healthcare • Biotechnology • US • USD

SharesGrow Score

62/100

3/6 Pass

SharesGrow Intrinsic Value

Praxis Precision Medicines, Inc. (PRAX) has 20 known insider and institutional holders on record. The largest holder is Clarus Lifesciences III, L.P. with 4,894,109 shares. Other notable holders include Adage Capital Management, L.P. and Reddy Kiran.

Over the last 12 months, insiders have made 38 transactions in PRAX stock — 17 buys (valued at $20.32M) and 0 sells (valued at RSU Award). Insider buying has outpaced selling during this period, which may signal confidence in the company's prospects.

PRAX Insider Ownership

Top Holder

Clarus Lifesciences III, L.P.

4,894,109 shares

Buys (12 mo)

$20.32M value

Sells (12 mo)

$0.00 value

12-Month Transaction Activity

Buy 45%

Sell 0%

Top Insider Holders

#	Name	Role	Shares Owned	Last Filed	Relative Size
1	Clarus Lifesciences Iii, L.p.	10 Percent Owner	4,894,109	2021-05-14	100%
2	Adage Capital Management, L.p.	10 Percent Owner	2,060,175	2025-10-17	42%
3	Reddy Kiran	Director	467,289	2020-10-15	10%
4	Bsof Parallel Master Fund L.p.	10 Percent Owner	423,946	2021-10-05	9%
5	Ravina Bernard	Chief Medical Officer	65,000	2022-06-24	1%
6	Sweeny Nicole	Chief Commercial Officer	38,619	2023-02-13	1%
7	Kelly Timothy Edwin	Chief Financial Officer	31,046	2026-01-13	1%
8	Sniecinski Megan	Chief Operating Officer	28,530	2026-01-13	1%
9	Nemiroff Alex	General Counsel and Secretary	25,933	2026-01-13	1%
10	Vitorovic Stefan	Director	22,753	2022-05-27	0%
11	Souza Marcio	Chief Executive Officer	22,110	2026-01-12	0%
12	Mastrocola Lauren	Principal Accounting Officer	13,446	2026-01-13	0%
13	Cudkowicz Merit Ester	Director	10,520	2025-06-27	0%
14	Mitchell Dean J	Director	10,520	2025-06-27	0%
15	Norden Gregory	Director	10,520	2025-06-27	0%
16	Desimone Jill	Director	10,520	2025-06-27	0%
17	Chodakewitz Jeffrey	Director	10,520	2025-06-27	0%
18	Young William D	Director	10,520	2025-06-27	0%
19	Kindler Jeffrey B	Director	224	2026-02-10	0%
20	Arbuckle Stuart A	Director	224	2026-02-10	0%

Recent Transactions (last 12 months)

Date	Name	Role	Type	Shares	Price	Value
2026-02-06	Arbuckle Stuart A	Director	RSU Award	224	$319.57	$71.58K
2026-02-06	Kindler Jeffrey B	Director	RSU Award	224	$319.57	$71.58K
2026-01-12	Kelly Timothy Edwin	Chief Financial Officer	Tax Withholding of RSU	943	$275.74	$260.02K
2026-01-12	Nemiroff Alex	General Counsel and Secretary	Tax Withholding of RSU	768	$275.74	$211.77K
2026-01-12	Mastrocola Lauren	Principal Accounting Officer	Tax Withholding of RSU	344	$275.74	$94.85K
2026-01-12	Sniecinski Megan	Chief Operating Officer	Tax Withholding of RSU	885	$275.74	$244.03K
2026-01-10	Kelly Timothy Edwin	Chief Financial Officer	Tax Withholding of RSU	1,335	$288.45	$385.08K
2026-01-08	Kelly Timothy Edwin	Chief Financial Officer	RSU Award	7,040	$294.38	$2.07M
2026-01-10	Nemiroff Alex	General Counsel and Secretary	Tax Withholding of RSU	917	$288.45	$264.51K
2026-01-08	Nemiroff Alex	General Counsel and Secretary	RSU Award	5,500	$294.38	$1.62M
2026-01-10	Mastrocola Lauren	Principal Accounting Officer	Tax Withholding of RSU	367	$288.45	$105.86K
2026-01-08	Mastrocola Lauren	Principal Accounting Officer	RSU Award	7,500	$294.38	$2.21M
2026-01-10	Sniecinski Megan	Chief Operating Officer	Tax Withholding of RSU	1,087	$288.45	$313.55K
2026-01-08	Sniecinski Megan	Chief Operating Officer	RSU Award	7,700	$294.38	$2.27M
2026-01-10	Souza Marcio	Chief Executive Officer	Tax Withholding of RSU	4,252	$288.45	$1.23M
2026-01-08	Souza Marcio	Chief Executive Officer	RSU Award	22,110	$294.38	$6.51M
2026-01-08	Arbuckle Stuart A	Director	Unknown	-	-	-
2026-01-08	Kindler Jeffrey B	Director	Unknown	-	-	-
2026-01-07	Kelly Timothy Edwin	Chief Financial Officer	Tax Withholding of RSU	139	$292.63	$40.68K
2026-01-07	Nemiroff Alex	General Counsel and Secretary	Tax Withholding of RSU	89	$292.63	$26.04K
2026-01-07	Mastrocola Lauren	Principal Accounting Officer	Tax Withholding of RSU	35	$292.63	$10.24K
2026-01-01	Sniecinski Megan	Chief Operating Officer	Unknown	11,999	$257.25	$3.09M
2026-01-07	Souza Marcio	Chief Executive Officer	Tax Withholding of RSU	405	$292.63	$118.52K
2025-12-30	Souza Marcio	Chief Executive Officer	Gift (Given)	400	-	-
2025-11-14	Kelly Timothy Edwin	Chief Financial Officer	RSU Award	384	$31.62	$12.14K