Upstream Bio, Inc. (UPB) has 11 known insider and institutional holders on record. The largest holder is Sutherland Everett Rand with 72,907 shares. Other notable holders include Deykin Aaron and GRAY MICHAEL.
Over the last 12 months, insiders have made 16 transactions in UPB stock — 11 buys (valued at $1.19M) and 5 sells (valued at $46.57K). Insider buying has outpaced selling during this period, which may signal confidence in the company's prospects.
UPB Insider Ownership
Top Holder
Sutherland Everett Rand
72,907 shares
Buys (12 mo)
11
$1.19M value
Sells (12 mo)
5
$46.57K value
12-Month Transaction Activity
Top Insider Holders
| # |
Name |
Role |
Shares Owned |
Last Filed |
Relative Size |
| 1 |
Sutherland Everett Rand |
Chief Executive Officer |
72,907 |
2026-03-17 |
|
| 2 |
Deykin Aaron |
Chief Medical Officer |
32,687 |
2026-03-17 |
|
| 3 |
Gray Michael |
CFO and COO |
29,648 |
2026-03-17 |
|
| 4 |
Houghton Adam |
Chief Business Officer |
24,301 |
2026-03-17 |
|
| 5 |
Fleming Harold Edward |
Director |
17,096 |
2025-06-12 |
|
| 6 |
Beckman Daniella |
Director |
17,096 |
2025-06-12 |
|
| 7 |
Ruddy Marcella K. |
Director |
17,096 |
2025-06-12 |
|
| 8 |
Renaud Ronald C Jr |
Director |
17,096 |
2025-06-12 |
|
| 9 |
Chimovits Erez |
Director |
17,096 |
2025-06-12 |
|
| 10 |
Ratcliffe Liam |
Director |
17,096 |
2025-06-12 |
|
| 11 |
Ambrose Allison |
General Counsel |
16,525 |
2026-03-17 |
|
Recent Transactions (last 12 months)
| Date |
Name |
Role |
Type |
Shares |
Price |
Value |
| 2026-03-16 |
Ambrose Allison |
General Counsel |
Informative Sell |
475 |
$9.29 |
$4.41K |
| 2026-03-16 |
Deykin Aaron |
Chief Medical Officer |
Informative Sell |
894 |
$9.29 |
$8.31K |
| 2026-03-16 |
Houghton Adam |
Chief Business Officer |
Informative Sell |
699 |
$9.29 |
$6.49K |
| 2026-03-16 |
Sutherland Everett Rand |
Chief Executive Officer |
Informative Sell |
2,093 |
$9.29 |
$19.44K |
| 2026-03-16 |
Gray Michael |
CFO and COO |
Informative Sell |
852 |
$9.29 |
$7.92K |
| 2026-01-02 |
Ambrose Allison |
General Counsel |
RSU Award |
17,000 |
- |
- |
| 2026-01-02 |
Deykin Aaron |
Chief Medical Officer |
RSU Award |
32,000 |
- |
- |
| 2026-01-02 |
Houghton Adam |
Chief Business Officer |
RSU Award |
25,000 |
- |
- |
| 2026-01-02 |
Sutherland Everett Rand |
Chief Executive Officer |
RSU Award |
75,000 |
- |
- |
| 2026-01-02 |
Gray Michael |
CFO and COO |
RSU Award |
30,500 |
- |
- |
| 2025-06-10 |
Ruddy Marcella K. |
Director |
RSU Award |
17,096 |
$11.59 |
$198.14K |
| 2025-06-10 |
Fleming Harold Edward |
Director |
RSU Award |
17,096 |
$11.59 |
$198.14K |
| 2025-06-10 |
Chimovits Erez |
Director |
RSU Award |
17,096 |
$11.59 |
$198.14K |
| 2025-06-10 |
Ratcliffe Liam |
Director |
RSU Award |
17,096 |
$11.59 |
$198.14K |
| 2025-06-10 |
Beckman Daniella |
Director |
RSU Award |
17,096 |
$11.59 |
$198.14K |
| 2025-06-10 |
Renaud Ronald C Jr |
Director |
RSU Award |
17,096 |
$11.59 |
$198.14K |
